BACKGROUND AND OBJECTIVE
To assess the long-term ophthalmological outcome of Parinaud syndrome.
PATIENTS AND METHODS
The files of 6 children with tumor-related Parinaud syndrome diagnosed and observed from 2000 to 2007 were reviewed. All had papilledema indicating increased intracranial pressure.
RESULTS
Mean presentation-to-diagnosis delay was 3.6 weeks. Treatment consisted of surgical shunting and complete or partial resection with adjuvant chemotherapy (n = 4) and radiation (n = 3). Visual acuity remained stable or improved in 8 of 9 eyes with 20/30 visual acuity at diagnosis; improved bilaterally in 1 patient from 20/100 to 20/25; and deteriorated bilaterally in 1 patient from 20/30 and 20/200 to counting fingers and hand motions, respectively. The most improvement was achieved within 4 months. Findings at follow-up (mean: 4.2 years) included up gaze limitation (minimal in 2 patients), abnormal convergence, convergence retraction nystagmus, and light-near dissociation. One child had bilateral optic atrophy.
CONCLUSION
Children with tumor-related Parinaud syndrome tend to have subtle but measurable residual ophthalmological findings years after diagnosis and treatment.
[Ophthalmic Surg Lasers Imaging 2010;41:467-471.]
AUTHORS
From the Department of Ophthalmology (NG-C, YR, MS), Rabin Medical Center, Beilinson Campus, Petach Tikva; the Pediatric Ophthalmology Unit (NG-C, YR, MS) and the Departments of Pediatric Radiology (LK), Oncology (HT, IJC), and Neurosurgery (SM), Schneider Children’s Medical Center of Israel, Petach Tikva; and the Sackler Faculty of Medicine (NG-C, JH, LK, HT, MS, IJC, SM), Tel Aviv University, Tel Aviv, Israel.
Originally submitted November 1, 2008. Accepted for publication January 9, 2010. Posted online April 29, 2010.
The authors have no financial or proprietary interest in the materials presented herein.
The authors thank Gloria Ginzach for her editorial assistance.
Address correspondence to Nitza Goldenberg-Cohen, MD, Pediatric Ophthalmology Unit, Schneider Children’s Medical Center of Israel, Petach Tikva 49202, Israel.
doi: 10.3928/15428877-20100426-02
